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This amplification cascades into increased BDNF-TrkB signaling, enhanced synaptic plasticity markers (PSD-95, synaptophysin), and upregulated dendritic spine density

However, its broad inhibitory activity may cause drug-drug interactions and hepatotoxicity, as ketoconazole can impair the metabolism of other co-administered compounds

Vitamin and mineral supplements are often used to help bridge these gaps and support overall health when taken appropriately

Therefore, combining glutathione with other markers that reflects various dysregulated molecular pathways, such as vitamin D, would likely result in a better approach for the early diagnosis of ASD